Abstract: Objective To observe the influence of amlodipine combined with perindopril on blood pressure viability(BPV) in elderly patients with essential hypertension. Methods From October,2014 to October,2015 in our hospital,82 patients with essential hypertension(EH) were divided into observation group and control group according to the random numbers(41 cases in each group). The control group were given amlodipine(10 mg/d),the observation group were given amlodipine(5 mg/d) combined with perindopril(4 mg/d),both groups were treated for eight weeks. 24 h ambulatory blood pressure was measured with noninvasive portable ambulatory blood pressure monitoring before and after the treatment. BPV was assessed using the standard deviation(SD) and coefficient variation(CV). Results In the control group,the SD for the systolic and diastolic blood pressure during the day and night at 24 h after the treatment day night were significantly lower than that before the treatment(P < 0. 05); While in the observation group,the SD and CV for the systolic and diastolic blood pressure during the day and night at 24 h after the treatment day night decreased significantly as compared with that before the treatment(P < 0. 05); After the treatment,both SD and CV in the observation group were lower than those in the control group(P < 0. 05). The total effective rate was 95. 1% in the observation group,which was significantly higher than 78. 0% in the control group(Z=- 3. 86,P < 0. 05); During the treatment,the routine urine and blood test results,functions of heart,liver and kidney were all within the normal range in both groups. And in the observation group,the incidence of adverse reactions was 6. 67%,which was significantly lower than 17. 1% in the control group(χ²=5. 615,P < 0. 05). Conclusion Amlodipine combined with perindopril can effectively reduce BPV of 24 hours systolic and diastolic blood pressure,with better curative efficacy and lower incidence of adverse reactions,and worthy of further promotion in clinics.