Abstract: Objective To evaluate the efficacy of five tone music therapy in patients with cardiovascular diseases. Methods We searched Pubmed,Embase,the Cochrane Central Register of Controlled Trials(CENTRAL),the ISI web of knowledge databases,CBM,VIP,CNKI,Chinese excellent degree thesis and Wanfang database for the papers that performed randomized controlled trial(RCT) between patients with cardiovascular diseases used five tone music therapy and patients not used five tone music therapy. The publishion time was between January 31,2000 to October 31,2015. Two people screened literature by following the inclusion and exclusion criteria independently,conducted data and quality assessment. Rev Man 5. 3 software was used to give the meta-analysis. Results Four papers including 322 subjects were included. The results of meta-analysis showed:the value of SAS score,SDS score,systolic and diastolic blood pressure were statistically significant between the intervention group and the control group(Z=3. 09,P=0. 002; Z=10. 81,P <0. 000 01; Z=2. 96,P=0. 003; Z=5. 24,P < 0. 000 01),the weighted average and 95% CI were- 7. 93(- 12. 95,- 2. 90),- 10. 28(- 12. 14,- 8. 41),- 2. 48(- 4. 12,- 0. 84),- 3. 09(- 4. 25,- 1. 94). Conclusion The five tone music therapy can improve anxiety,depression,systolic and diastolic blood pressure for patients with cardiovascular diseases. It still needs high-quality,large sample,carefully designed randomized controlled trials to present a further confirmation.