Abstract: Objective To investigate the effect of health integration approach combined with patient self-efficacy training on anxiety,depression and quality of life of patients with drug-resistant tuberculosis. Methods The 120 retreated pulmonary tuberculosis patients in our hospital from January,2010 to January,2014 were randomly divided into control group and observation group with 60 cases in each group.All patients were treated with a standardized drug-resistant tuberculosis treatment programs,the course was 12 months.The medical care integrated manner was performed in both groups.The observation group received additional self-efficacy training.Anxiety score(SAS) and depression scale score(SDS) Scale were used to evaluate the depression and anxiety of patients before and after the treatment;Quality of Life Assessment Scale(WHOQOL-BREF) was used to measure the QOL of patients before and after the treatment.One year follow up was carried to observe the incidence of hemoptysis again and recurrence rate. Results After the treatment,SAS and SDS scores in both groups were decreased when compared with the values before treatment,and more obviously in the observation group,the difference was statistically significant(P<0.05).After the treatment,the scores for each item increased obviously in both groups,especially in the observation group,the difference was statistically significant(P<0.05).The rate and volume of hemoptysis again and the recurrence rate in the observation group was significantly lower than that in the control group,the difference was statistically significant(P<0.05). Conclusion The health care integration combined with evaluation of self-efficacy can more effectively improve the psychological conditions,quality of life and treatment compliance in patients with drug-resistant tuberculosis when compared with the health care integration alone,which is worthy of clinical application.