Abstract: Objective To investigate the influence of Huoba Huagen tablets combined with valsartan on renal function and lipid metabolism of patients with diabetic nephropathy(DN),and to provide support for its clinical application. Methods A total number of 184 cases of diabetic nephropathy in our hospital from January,2015 to December,2015 were enrolled and randomly divided into control group and observation group by random number method with 92 cases in each group.The patients in the control group were given valsartan,while the patients in the observation group were administrated with Huoba Huagen tablets and valsartan.Before and after the treatment,the renal function indicators[24 h urinary protein(QUP),24 h urinary albumin excretion rate(UAER),serum creatinine(Scr)]and lipid metabolism[cholesterol(TC),triglyceride(TG),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C)] levels of both groups were tested,and the therapeutic efficacy was documented.SPSS 18.0 was used to compare the difference in renal function indicators and lipid metabolism between the two groups. Results After the treatment,the levels of UAER,QUP and Scr in both groups were significantly reduced(P<0.05),especially in the observation group,the difference was significant as compared with the control group(P<0.05);after the treatment,the levels of TC,TG and LDL-C of both groups were significantly reduced(P<0.05),and more obviously in the observation group as compared with the control group(P<0.05).The total efficacy of the observation group was 87.0%,which was significantly higher than 0.7% of the control group(P<0.05). Conclusion Huoba Huagen tablets combined with valsartan can effectively improve renal function and lipid metabolism of patients with diabetic nephropathy with a satisfactory efficacy.