Abstract: Objective To study the perioperative nursing plan of total knee arthroplasty,so as to improve effectively the postoperative recovery and life quality of patients,and shorten the length of hospital stay. Methods Total 80 patients undergoing total knee arthroplasty in our department of between April,2015 and April,2016 were divided into experimental group and control group according to random number table with 40 cases in each group.The control group was given the routine nursing care,while the experimental group was given a comprehensive perioperative nursing.The postoperative pain and the hospital for special surgery(HSS) score at 2 weeks,1 month,3 months and 6 months after the operation were recorded in both groups;the time for patients to achieve more than 90 degree knee flexion and postoperative hospital stay were compared between the two groups. Results The pain visual analog scale(VAS) score at postoperative 6 h,12 h and 24 h in the experimental group was lower than that in the control group,the difference was statistically significant(P<0.05);The time for patients to achieve more than 90 degree knee flexion and postoperative hospital stay in the experimental group were all less than those in the control group,the difference was statistically significant(P<0.05).HSS score at 2 weeks,1 month,3 months and 6 months after the operation in both groups were improved,however,the difference between the two groups was statistically significant(P<0.05). Conclusion The high-quality care for the total knee arthroplasty patients can effectively reduce postoperative pain,shorten the length of hospital stay,and improve the postoperative recovery and quality of life of patients,which has important significance on the development orthopedic surgery nursing.