Abstract: Objective To describe the clinical application value of implant biliary metal/plastic stents by endoscopic retrograde cholangiopancreatography (ERCP) to cure malignant obstructive jaundice. Methods We analyzed 68 cases of malignant biliary obstruction by endoscopic stenting between January 1,2011 to December 31,2014 in the Second Affiliated Hospital of Wenzhou Medical University. Results In this study,68 patients,46 male and 22 females,aged 28 to 99 years,mean age (67.57±12.78) years.Before the treatment,serum total bilirubin (TBil) was (217.72±125.54)μmol/L,and decreased to (149.24±126.92)μmol/L after one week treatment;serum direct bilirubin (DBil) was (126.46±70.69)μmol/L,and decreased to (75.55±68.66)μmol/L on after e week treatment,the difference was statistically significant (P<0.05);after the treatment,other liver function indicators also decreased significantly.14 caught a poor effect in diminishing jaundice,with a rate of 79.41% at one week after stent implanting.The mean survival time of patients was (10.13±10.49) months. Conclusion Endoscopic stenting for malignant biliary obstruction can improve the quality of life of patients,prolong survival,and have many advantages,such as safe,simple,minimally invasive,repeatable and so on.It is an effective way to treat malignant obstructive jaundice.