Abstract: Objective In clinical practice,we found some patients with Liver-Yang hyperactivity syndrome high Hcy (H type) hypertension did not respond well to treatment for Hcy and blood pressure.Patients still experienced dizziness or headache after treatment.We sought to investigate the therapeutic effect of folic acid,Enalapril,and Qiangli Dingxuan Tablets integrated Chinese and Western medicine treatment for Liver-Yang hyperactivity syndrome high Hcy (H type) hypertension. Methods We recruited 100 patients from October,2014 to June,2015 newly diagnosed as Liver-Yang hyperactivity syndrome high Hcy (H type) hypertension stage 1 and 2 as our study cases.They were divided randomly by software into intervention group and control group,with 50 patients for each.Intervention group was treated orally with Enalapril 10 mg/d,folic acid 0.8 mg/d,and Qiangli Dingxuan Tablets 4 pieces per time,three times per day.Control group was treated orally with Enalapril 10 mg/d and folic acid 0.8 mg/d.During treatment,the change of blood pressure,Hcy values,the recognition and the symptom of Traditional Chinese Medicine constitution were observed.Continuous variables were recorded as mean±standard error,and were analyzed with student t test.Categorical variables were analyzed with chi-square test,and ranked data were evaluated with Wilcoxon rank sum test.Statistical significances were achieved as P<0.05. Results The total effective rate of the intervention group was 88%(44/50),while 30%(15/50) for the control group.The total effective rate of the intervention group was significantly higher than the control group,and the difference reached statistical significance (P<0.01).After three-month treatment,the average systolic blood pressure (SBP)/diastolic blood pressure (DBP) of the intervention group were both lower than those in the control group,and the difference was statistically significant (P<0.05).The difference of Hcy values between the intervention group and the control group failed to reach statistical significance (P>0.05).And the intergroup difference of the Liver-Yang hyperactivity syndrome scores between the intervention group and the control group was statistically significant (P<0.05). Conclusion Integrated Chinese and Western treatment for Liver-Yang hyperactivity syndrome H type hypertension has a decent therapeutic effect.Not only did it effectively control H type hypertension,but also significantly improved Liver-Yang hyperactivity symptoms like dizziness and headache.