彩色多普勒频谱和超声造影定量分析在慢性肾炎治疗前后肾脏微循环评估中的价值

孙建明; 郑媛媛; 江珍珍

doi:10.16766/j.cnki.issn.1674-4152.2017.01.038

彩色多普勒频谱和超声造影定量分析在慢性肾炎治疗前后肾脏微循环评估中的价值

doi: 10.16766/j.cnki.issn.1674-4152.2017.01.038

绍兴市人民医院超声科, 浙江绍兴 312000

基金项目:

2015年浙江省医药卫生一般项目(2015KYA220)

详细信息

通讯作者:
孙建明,E-mail:sjmazjm@163.com

中图分类号: R445.1;R692.3
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出版历程
- 收稿日期: 2016-10-11

Value of color Doppler spectrum and quantitative contrast enhanced ultrasound on evaluation of renal microcirculation before and after treatment of chronic glomerulonephritis

Department of Ultrasound, Shaoxing People's Hospital, Shaoxing, Zhejiang 312000, China

摘要

摘要: 目的探讨彩色多普勒频谱和超声造影定量在慢性肾炎治疗前后肾脏微循环评估中的价值。方法选择绍兴市人民医院2014年1月-2015年12慢性肾炎患者50例作为研究对象,根据治疗效果将其分为预后良好组和预后不良组。测定治疗前后血尿素氮、血肌酐、24 h尿蛋白定量,彩色多普勒频谱测定肾段动脉血流阻力指数及段动脉最大血流速度,超声造影测定平均通过时间、曲线下面积、峰值强度及达峰时间。结果治疗后血尿素氮、血肌酐、24 h尿蛋白定量、肾脏长径和肾脏厚径与治疗前比较差异无统计学意义(P>0.05)。治疗后段动脉阻力指数和段动脉最大流速和治疗前比较差异无统计学意义(P>0.05)。慢性肾炎患者治疗后曲线下面积高于治疗前(P<0.05)。治疗前,预后良好组和预后不良组平均通过时间、达峰时间、曲线下面积和峰值强度比较差异均无统计学意义(P>0.05);治疗后,预后良好组平均通过时间、达峰时间、曲线下面积和峰值强度均高于预后不良组(P<0.05)。治疗前后24 h尿蛋白定量差值与曲线下面积差值呈负相关(r=-0.901,P<0.001)。结论慢性肾炎患者治疗前后生化指标及彩色多普勒频谱参数无显著变化,超声造影能够敏感反应慢性肾炎患者治疗前后肾脏微循环的变化情况。
- 彩色多普勒频谱 /
- 超声造影 /
- 慢性肾炎
Abstract: Objective To explore the value of color Doppler spectrum and quantitative contrast enhanced ultrasound on evaluation of renal microcirculation before and after treatment of chronic glomerulonephritis. Methods Fifty cases of chronic glomerulonephritis in our hospital between January,2014 and December,2015 were enrolled and divided into good prognosis group and poor prognosis group according to the therapeutic effect.The levels of blood urea nitrogen,serum creatinine and 24-hour urine protein were tested before and after the treatment.The renal arterial resistance index (RRI) and maximal blood flow velocity were measured by color Doppler spectrum.The mean transit time,area under the curve,peak intensity and time to peak were measured by contrast-enhanced ultrasonography. Results There was no significant difference of blood urea nitrogen,serum creatinine,24 h urinary protein,The long axis of the kidney and the thickness of the kidney after treatment and those before treatment (P>0.05).There was no significant difference in the resistance index and the maximal velocity of segmental artery after treatment and those before treatment (P>0.05).The area under the curve after treatment was higher than that before treatment (P<0.05).Before treatment,there were no significant differences in the mean transit time,peak time,area under the curve and peak intensity between the two groups (P>0.05).After treatment,the mean transit time,peak time,area under the curve and peak intensity of the good prognosis group were higher than that of the poor prognosis group (P<0.05).There was a negative correlation between the difference of urinary protein before and after treatment and the area under the curve before and after treatment (r=-0.901,P<0.001). Conclusion There are no significant changes in biochemical parameters and color Doppler spectrum parameters before and after treatment in patients with chronic glomerulonephritis.Contrast-enhanced ultrasound can be sensitive to the changes of renal microcirculation in patients with chronic glomerulonephritis before and after treatment.
- Color Doppler spectrum /
- Contrast-enhanced ultrasound /
- Chronic nephritis