Abstract: Objective To investigate the clinical value of application infertility by transvaginal color Doppler ultrasound,and to observe the evaluation value of the endometrium of patients with arterial blood flow,provide a strong reference for clinical diagnosis and treatment of infertility. Methods In this study,Select the control group and the observation group study mode 1,our hospital in December,2013-December,2015 were treated 185 cases of primary infertility in female patients as observed in this group,and the other choose healthy women over the same period 120 cases of healthy people-oriented study group.Application of transvaginal color Doppler ultrasound in the menstrual cycle,respectively 8-11 d,the first 13-16 d and the second 20-24 d were detected uterine artery peak systolic velocity (PSV),endometrial thickness,resistance index (RI) and pulsatility index (PI).Endometrial thickness subject uterine long axis image prevail,then the pre-test subjects Palace uterine body lines,endometrial total thickness to diameter;the same time,the data obtained during the study were statistically analyzed. Results Observation group were different periods in endometrial thickness were significantly less than the control group,P<0.05;and the PSA was significantly slower than the control group,P<0.05.Observation group was significantly higher in the PI and RI values for different time periods,P<0.05. Conclusion Through the application of transvaginal color Doppler ultrasound can effectively understand and grasp infertility Hemodynamics and endometrial thickness,and thereby effectively evaluate patients with endometrial receptivity for clinical diagnosis and treatment programs choose to provide a reference,it will help protect the safety of patients.