The clinical study of the electroacupuncture for treatment of amnestic mild cognitive impairment
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摘要: 目的 观察电针疗法对遗忘型轻度认知功能障碍(amnestic mild cognitive impairment,aMCI)认知功能的改善作用,探究其可能机制。 方法 60例aMCI患者被随机分为治疗组和对照组。治疗组接受电针疗法,对照组口服尼莫地平,疗程8周。通过量表和事件相关电位(ERP)检查评估认知功能,检测高敏C-反应蛋白(high sensitivity C-reactive protein,hs-CRP)和白细胞介素-6(interleukin-6,IL-6)水平,核磁共振弥散张量成像(DTI)扫描以及静息功能磁共振成像。 结果 治疗后MMSE、MoCA、CDT评分均显著升高(P<0.05),电针治疗组疗效更好,差异具有统计学意义(P<0.05)。ERP提示患者认知功能得到改善(P<0.05)。hs-CRP和IL-6水平显著降低(P<0.05)。感兴趣区FA值有所升高(P<0.05),静息功能磁共振成像上左侧颞叶、左侧海马旁回、枕叶、舌回、楔前叶的局部一致性(ReHo)降低,并在治疗后升高(P<0.05),组间差异无统计学意义。 结论 电针疗法对aMCI疗效与尼莫地平相当,其改善认知功能水平优于尼莫地平,其机制可能与降低血清IL-6有关。Abstract: Objective To observe the curative effect of electric acupuncture treatment on aMCI patients and to explore its possible mechanisms. Methods Sixty patients got randomly assigned to treatment group or control group,and each group contained 30 cases.The patients in treatment group received electric acupuncture treatment,and the patients in control group were treated with oral nimodipine.The total score of MOCA,MMSE,CDT and ERP check were used to assess the patient's cognitive function before and after treatment with the level of high sensitivity C-reactive protein (hs-CRP) and interleukin-6(IL-6) in serum were checked.Meanwhile,the DTI and rs-fMRI were applied to measure FA value and ADC value on patients'ROI. Results The total score of MOCA,MMSE and CDT significantly increased after treatment (P<0.05).ERP demonstrated that the cognitive function in patients of two groups were improved and the level of hs-CRP and IL-6in serum decreased significantly (P<0.05).DTI indicated that FA value rose after the treatment. Conclusion Electric acupuncture treatment can significantly improve the cognitive function on aMCI patients and the mechanism may be associated with lower serum IL-6.
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