Abstract: Objective To explore the effects of sevoflurane combined with propofol intravenous-inhalation anesthesia on somatosensory evoked potential (SEP) and motor evoked potential (MEP) in patients with scoliosis correction surgery and compared with the propofol intravenous anesthesia. Methods Total 60 cases of adolescent idiopathic scoliosis with scoliosis correction surgery in our hospital from January,2013 to January,2016 were recruited and randomly divided into group A (propofol intravenous anesthesia) and group B (sevoflurane combined with propofol intravenous-inhalation anesthesia) with 30 cases in each group.The general condition (weight,operative time,bleeding loss volume),hemodynamics parameters (heart rate and arterial pressure at each time point),success rate of SEP and MEP,as well as the time to anesthetic awareness and extubation were recorded.The independent-samples T test was performed for data comparison and analysis by SPSS 19.0. Results There were no statistical difference in the operation time (t=0.15,P=0.87),blood loss (t=0.33,P=0.74),success rate of MEP (t=0.00,P=1.00) and SEP (t=0.00,P=1.00) between the two groups.The time to anesthetic awareness (t=4.47,P=0.00) and extubation (t=3.60,P=0.00) in group B were shorter than those in the group A. Conclusion The patients undergoing sevoflurane combined with propofol intravenous-inhalation anesthesia during scoliosis correction surgery may recovery from anesthetic quickly,which is beneficial to the evaluation of the postoperative neurological function.