Abstract: Objective To investigate the clinical value of ECG and cardiac markers detection in the diagnosis and treatment of infantile viral pneumonia. Methods A total of 90 cases of infantile viral pneumonia in our hospital from June,2015 to May,2016 were enrolled and divided into common group[n=43,male 23 cases and female 20 case,average age (2.8±1.3) years]and severe group[n=47,male 25 cases and female 22 case,average age (2.7±1.4) years]according to disease severity,while 40 health individuals[male 20 cases and female 20 case,average age (2.3±1.3) years]during the same period were selected as control group.The treatment course was 7 d in the common and severe group.The ECG and levels of cardiac markers (CK,CK-MB,CTnT) were tested and compared among the three groups before and after the treatment. Results Before the treatment,62.79% of infantile pneumonia patients appeared abnormal electrocardiogram in the common group,and 87.23% in severe group;the levels of CK,CK-MB and CTnT of the common and severe group were significantly higher than those in the control group (P<0.05),and the severe group increased more significantly than those in common group (P<0.05);After the treatment,ECG was improved in most cases,and the levels of CK,CK-MB and CTnT decreased significantly in common and severe group (P<0.05),the levels of CK,CK-MB and CTnT recovered to normal range in the common group (P>0.05),and levels of CK,CK-MB and CTnT of the severe group were significantly higher than those in the common and the control group (P<0.05). Conclusion There were abnormalities in ECG and cardiac markers in patients with infantile pneumonia.ECG and cardiac markers detection mat contribute to the diagnosis and prognosis of infantile pneumonia.