Abstract: Objective To investigate the effect of high-dose gamma globulin (IVIG) combined aspirin (ASP) on T lymphocyte subsets,vascular endothelial growth factor,and inflammatory factors of children with Kawasaki disease. Methods A total of 36 cases of children with Kawasaki disease patients treated with high-dose IVIG combined ASP were assigned into observation group,and 36 cases of healthy children in the same period into control group.The T lymphocyte subsets[CD4⁺、CD4⁺/CD8⁺、CD8⁺)],vascular endothelial related indicators[vascular endothelial growth factor (VEGF),endostatin (ES),endothelial nitric oxide synthase (eNOS)],and serum inflammatory cytokines[tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein (hs-CRP),interleukin-10(IL-10),serum procalcitonin (PCT)]of both groups were tested and compared.The clinical effect was evaluated and compared. Results After the treatment,CD4⁺ and CD4⁺/CD8⁺ of the observation group were significantly decreased as compared with those before the treatment (P<0.05),CD8⁺ level was significantly increased (P<0.05).After the treatment,VEGF and ES levels of the observation group were significantly decreased as compared to those before the treatment (P<0.05),eNOS level was significantly increased (P<0.05).After the treatment,the levels of TNF-α,hs-CRP,IL-10 and PCT were decreased significantly (P<0.05).After the treatment,the total effective rate was 88.9%. Conclusion High-dose gamma globulin combined aspirin can improve immune function,vascular endothelial growth factor and inflammation factor of children with Kawasaki disease,and slow the progression of disease with a satisfaction effect.