Abstract: Objective To explore the influence of the key knowledge guide of hypertension prevention and control provided by the family physician on the signed patients'cognition,which includes normal blood pressure values of human body,daily salt intake,the need for taking antihypertensive medication after reaching normal blood pressure level and whether it is advisable to prevent and control blood pressure as soon as possible. Methods On the basis of informed consent,accepting monitoring management of hypertension in Shanghai Tianmuxi community health center more than one year,405 signed patients with hypertension constitute the study group,while 276 hypertensive patients who continue to maintain the original public health personnel telephone or on-site follow-up make up the control group.In accordance with the requirements of the revised edition of "Chinese Hypertension Prevention Guide 2010",both groups received blood pressure monitoring and hypertension knowledge guidance according to the study of blood pressure grades and risk stratification factor group management. Results The age composition of the patients,gender,severity of the hypertension of 681 subjects shows no statistical differences between the two groups (P>0.05) by means of t test,indicating that the background of the two groups has no difference.But the understanding of the study group about the four most critical prevention knowledge was higher than that of the control group,with statistical significance (P value <0.01 or <0.05) via chi-square test. Conclusion The family doctor can help guide the key to prevention and treatment of high blood pressure,have a positive impact on the promotion of their own blood pressure control.At the same time,it helps to promote the further development of Shanghai family doctor system.