Abstract: Objective To investigate the distribution of the TCM constitution types in COPD patients with depression and its relationship with COPD exacerbation,providing evidence for the prevention and treatment of COPD and COPD exacerbation. Methods Five hundred cases COPD with depression patients in outpatient and hospitalization of the Third Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine and Hangzhou Zhoupu community health service center from June,2014 to December,2016 were selected.Patients were composed by 260 cases male and 240 cases female with age range from 40 to 85.Based on TCM constitution theory,questionnaire was designed and data were collected from 500 patients of COPD with depression to investigate the relationship with COPD exacerbation. Results In all 500 patients,gentleness type patients were 20 cases (4.0%) and biased constitution were 480 cases (96.0%) including 112 cases of Qi asthenia (22.4%),97 cases of phlegm-dampness (19.4%),88 cases of Yang asthenia (17.6%),73 cases of damp-heat (14.6%),42 cases of Yin asthenia,33 cases of blood stasis,24 cases of Qi Stagnation,and 11 cases of special inherited type.Among the nine types of TCM Constitution in COPD patients with depression,Qi asthenia,phlegm-dampness,Yang asthenia and damp-heat were significantly correlated. Conclusion Qi asthenia,phlegm-dampness,Yang asthenia and damp-heat were the predominant constitution types in COPD patients with depression.It conformed to the pathological characteristics of deficiency essence with virtual reality and to provide clinical basis for the practice of "treating disease" in TCM.