Abstract: Objective To investigate the effect of dexmedetomidine in anesthesia for functional neurosurgery,and to provide scientific theoretical basis for clinical selection of anesthesia. Methods A total of 337 patients undergoing functional neurosurgery in our hospital from May,2015 to May,2016 were randomly divided into observation group (n=169) and control group (n=168).The observation group received dexmedetomidine intravenous injection (1 μg/kg,10 min),continuous intravenous infusion of 0.4 μg/(kg·h),while the control group was given normal saline by intravenous injection.Both groups were given intravenous anesthesia induction and maintenance with propofol.The level of MAP,HR,SpO₂,Ramsay sedation score,RR,OAA/S sedation score at the time points before the induction,after the surgery and awareness recovery were recorded and compared.The response capability during wake-up period and adverse reactions were also compared between the two groups.SPSS 19 was used for statistical data processing. Results The level of MAP and HR in the observation group were all statistically lower than those of in the control group after the surgery and awareness recovery (P<0.05),and the Ramsay sedation score of the observation group were all statistically higher than that of the control group respectively (P<0.05).After the surgery,the OAA/S sedation score was statistically less in the observation group than that in the control group.However,OAA/S sedation score during awareness recovery was statistically greater in the observation group than that of in the control group (P<0.05).One hundred and forty-eight cases (87.57%) were response significantly during wake-up period in the observation group and which was higher than that in the control group (121 cases,72.02%)P=0.021.7 cases (4.14%) with adverse reactions in the observation group was lower than 11 cases (6.55%) in the control group of,and there was no statistical difference (P=0.326). Conclusion The clinical efficacy of dexmedetomidine in anesthesia for functional neurosurgery is obvious.It can effectively play a sedative effect,and increase the response ability during wake-up period.It is worthy of popularization and application.