麝香保心丸联合辛伐他汀与单用辛伐他汀治疗冠心病合并高脂血症的疗效比较

宋伟; 林祖近; 蔡海鹏; 徐玉顺

doi:10.16766/j.cnki.issn.1674-4152.2017.04.023

麝香保心丸联合辛伐他汀与单用辛伐他汀治疗冠心病合并高脂血症的疗效比较

doi: 10.16766/j.cnki.issn.1674-4152.2017.04.023

台州市中心医院心血管内科, 浙江台州 318000

详细信息

通讯作者:
宋伟,E-mail:songwei6658@163.com

中图分类号: R541.4;R589.2
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- 被引次数: 0
出版历程
- 收稿日期: 2016-07-15
- 网络出版日期: 2022-08-06

A comparative study of combination therapy with Shexiang Baoxin pill and simvastatin and simvastatin alone on coronary artery disease with hyperlipidemia

Department of Cardiology, Taizhou Central Hospital, Taizhou, Zhejiang 318000, China

摘要

摘要: 目的探讨麝香保心丸联合辛伐他汀与单用辛伐他汀治疗冠心病合并高脂血症的临床效果。方法将192例冠心病并高脂血症患者以随机数字法分为2组,每组96例。对照组给予辛伐他汀,观察组在对照组基础上给予麝香保心丸。治疗前后,对2组患者血脂水平如总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C),心脏功能相关参数如射血分数(LVEF)、每分钟心输量(CO)、心脏指数(CI)、左室舒张末内径(LVEDD),血流变指标包括全血高切黏度(HBV)、全血低切黏度(LBV)、全血中切黏度(MBV)、血浆黏度(PV)、纤维蛋白原(FIB)、内皮素-1(ET-1)进行检测,并对2组临床治疗效果进行观察。结果治疗后,2组TC、TG、LDL-C水平显著降低,2组HDL-C水平显著升高(P<0.05);且观察组治疗前后TC、TG、LDL-C、HDL-C水平变化显著高于对照组(P<0.05)。治疗后,2组LVEF、CO、CI水平显著升高,LVEDD水平显著降低(P<0.05);且观察组治疗前后LVEF、CO、CI、LVEDD水平变化显著高于对照组(P<0.05)。治疗后,2组HBV、LBV、MBV、PV、FIB水平明显降低(P<0.05);且观察组治疗前后HBV、LBV、MBV、PV、FIB水平变化显著高于对照组(P<0.05)。治疗后,2组内皮素水平均下降(P<0.05),观察组治疗前后ET-1水平变化显著高于对照组(P<0.05);治疗总有效率为94.8%,显著高于对照组的86.5%(P<0.05)。结论麝香保心丸联合辛伐他汀可以有效治疗冠心病合并高脂血症,可以改善患者血脂、心脏功能、血液流变学,且效果优于单用辛伐他汀。
- 麝香保心丸 /
- 辛伐他汀 /
- 冠心病 /
- 高脂血症
Abstract: Objective To investigate the clinical effect of Shexiang Baoxin pill combined with simvastatin on coronary artery disease with hyperlipidemia,and compare with simvastatin alone. Methods Total 192 cases of coronary heart disease with hyperlipidemia were randomly divided into two groups by random number method with 96 cases in each group.The patients in the control group were given simvastatin,while the patients in the observation group received additional Shexiang Baoxin pill.Before and after the treatment,the lipid levels (TC,TG,LDL-C,HDL-C),cardiac function parameters (LVEF,CO,CI,LVEDD),blood viscosity indicators (HBV,LBV,MBV,PV,FIB),endothelin-1(ET-1) of both groups were tested,and the clinical effects of the two groups were observed. Results After the treatment,TC,TG,LDL-C levels of the two groups were significantly decreased (P<0.05),and HDL-C levels were significantly increased (P<0.05);and before and after treatment,the levels of TC,TG,LDL-C,HDL-C levels of the observation group were significantly higher than those of the control group (P<0.05).After the treatment,LVEF,CO and CI of both groups were significantly increased (P<0.05),and LVEDD levels were significantly decreased (P<0.05);and before and after the treatment,changes of LVEF,CO,CI,LVEDD levels of the observation group were significantly higher than those of control group (P<0.05).After the treatment,HBV,LBV,MBV,PV,FIB levels of the two groups were significantly decreased (P<0.05);and before and after the treatment,the changes of HBV,LBV,MBV,PV,FIB levels of the observation group were significantly higher than those of the control group (P<0.05).After the treatment,ET-1 levels of the two groups were significantly decreased (P<0.05),and before and after the treatment,the change of ET-1 level of the observation group was significantly higher than that of the control group (P<0.05).The total effective rate of the observation group was 94.8%,significantly higher than 86.5% of the control group (P<0.05). Conclusion Shexiang Baoxin pill combined with simvastatin is effective on coronary artery disease with hyperlipidemia through improve the condition of blood lipid,cardiac function and blood rheology parameters.The clinical effect of Shexiang Baoxin pill combined with simvastatin was better than that of simvastatin alone.
- Shexiang Baoxin pill /
- Simvastatin /
- Coronary heart disease /
- Hyperlipidemia