Abstract: Objective To analyze the risk factors of depression in patients with hospitalized viral hepatitis cirrhosis,and investigate the effects of psychological nursing intervention. Methods Two hundred cases of hospitalized viral hepatitis cirrhosis patients in our hospital from January,2014 to December,2015 were retrospectively analyzed.The depression status of patients was detected by self-rating depression scale (SDS),and the risk factors were analyzed by univariate analysis.And the depression patients were randomly divided into two groups.Observation group was given psychological nursing intervention,and control group was given routine nursing.The depression changes of patients were detected by psychosomatic symptoms self-rating scale (SCL-90) and SDS to evaluate the effect of psychological nursing. Results The depression incidence of hospitali zed viral hepatitis cirrhosis patients was 47.0%,mainly including mild and moderate depression.Younger age,lower degree,smaller family income,severe liver cirrhosis,time of Hepatitis B infection>5 year were the risk factors of depression in patients.After psychological nursing intervention,the each index in SCL-90(somatization,coercion,interpersonal relationship,depression,anxiety,hostility,horror,mental symptoms) and SDS scores of observation group were significantly reduced compared to that before psychological nursing (P<0.05),and significantly lower than those of control group (P<0.05). Conclusion Hospitalized viral hepatitis cirrhosis patients easily occurred depression,and younger age,lower degree,smaller family income,severe liver cirrhosis,time of Hepatitis B infection>5 year were its risk factors.Psychological nursing intervention could effectively improve their depression.Therefore,risk factors of depression in Hepatitis B cirrhosis patients should be draw attention,and psychological nursing should be carried out to improve the patient's psychological state.