Abstract: Objective Observation of blood pressure regulation combined with completely mechanical ventilation in the treatment of patients with severe craniocerebral trauma after craniotomy.The cerebral oxygen uptake rate (CERO₂) after surgery,the improvement rate and mortality rate in 3 months were observed,the influence of the method on the prognosis of severe craniocerebral trauma were observed. Methods Fifty-four cases of severe craniocerebral trauma patients from July,2013 to June,2015 were selected and randomly divided into observation group and control group by means of random number table,28 cases in the observation group and 26 cases in the control group.The control group was given conventional ICU treatment.The observation group was given conventional ICU treatment,blood pressure regulation and complete mechanical ventilation.Compare the two groups with general situation,24,48,72 hours CERO₂ changes before and after the surgery.Followed up with patients for 3 months or end point events (death).Compare the prognosis of the two groups. Results The use time of the breathing machine observation group was significantly longer than that of the control group (P< 0.05).The observation group after surgery 24,48,72 hours of CERO₂ was significantly reduced,compared with the preoperative and control group,the difference was statistically significant (P<0.05),which showed that the treatment method had a certain effect on reducing the CERO₂.The improvement rate of observation group was 53.57% and control group was 15.38%,the mortality rate of observation group was 3.57% and control group was 30.77%,the improvement rate of observation group was higher than that of control group,the mortality rate was lower than the control group,the difference was statistically significant (P<0.05). Conclusion The blood pressure control combined with completely mechanical ventilation can reduce the CERO₂ in the patients with severe traumatic brain trauma and improve patient outcomes.Attention should be paid to the prevention and treatment of ventilator associated nosocomial infection.