Abstract: Objective To investigate the clinical effect of Mudan granule combined Mecobalamin on diabetic peripheral neuropathy. Methods Ninety-eight cases of diabetic peripheral neuropathy patients were randomly divided into 2 groups (49 cases in each group).The control group was given mecobalamin,and observation group was given Mudan granule based on control group.Before and after treatment,serum biochemical parameters[serum total cholesterol (TC),triglyceride (TG),whole blood high shear viscosity (HBV),whole blood low shear viscosity (LBV)],clinical symptom score (Limb numbness and tingling sensation,acral temperature sensory disturbance,acral reflex sensitivity and limb weakness),nerve conduction velocity[motor nerve conduction velocity (MNCV) and sensory conduction velocity (SNCV) of median nerve,common peroneal nerve and anterior tibial nerve]of two groups were detected,and the clinical effect of two groups were accounted. Results After treatment,the TC,TG,HBV and LBV levels of two groups were significantly reduced (P<0.05);and TC,TG,HBV and LBV levels of observation group were significantly lower than control group (P<0.05).After treatment,limb numbness and tingling sensation,acral temperature sensory disturbance,acral reflex sensitivity and limb weakness of two groups were significantly reduced (P<0.05);and limb numbness and tingling sensation,acral temperature sensory disturbance,acral reflex sensitivity and limb weakness of observation group were significantly lower than control group (P<0.05).After treatment,median nerve,common peroneal nerve and anterior tibial nerve MNCV and SNCV of two groups were significantly increased (P<0.05);and median nerve,common peroneal nerve and anterior tibial nerve MNCV and SNCV of observation group were significantly higher than control group (P<0.05).The total effective rate of the observation group was 89.8%,which was significantly higher than control group (73.5%,P<0.05). Conclusion Mudan granule combined Mecobalamin could significantly improve the clinical symptoms of diabetic peripheral neuropathy with satisfactory effect.