Correlation between Th17-related cytokines in induced sputum and BODE index and GOLD degree among patients with COPD
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摘要: 目的 分析慢性阻塞性肺疾病(COPD)患者诱导痰Th17细胞相关细胞因子水平及其与BODE指数和GOLD分级的相关性。 方法 选取53例急性加重期COPD患者为研究对象,同期入院体检的40例健康志愿者为对照组,分别于治疗前(AE-COPD组)和治疗后稳定期(S-COPD组)取痰诱导液,采用ELISA试剂盒测定Th17相关细胞因子IL-23、IL-1β、IL-17A及IL-17F水平,并分析其与患者BODE指数和GOLD分级的相关性。 结果 AE-COPD组和S-COPD组IL-23、IL-1β、IL-17A、IL-17F水平显著高于对照组(P<0.05),且AE-COPD组IL-23、IL-1β、IL-17A、IL-17F水平显著高于S-COPD组(P<0.05)。AE-COPD组BODE指数和GOLD分级均显著高于S-COPD组(P<0.05)。相关分析结果显示急性期IL-23、IL-1β、IL-17A、IL-17F水平与BODE指数和GOLD分级呈正相关性(P<0.05),稳定期IL-17A、IL-17F水平与BODE指数和GOLD分级呈正相关性(P<0.05)。 结论 IL-23、IL-1β、IL-17A、IL-17F均参与了COPD的发生和发展,急性期各指标水平与BODE指数和GOLD分级呈正相关性。Abstract: Objective To detect the level of Th17-related cytokines in induced sputum and analyze its correlation with BODE index and GOLD degree among the patients with chronic obstructive pulmonary disease (COPD). Methods Fifty-there patients with chronic obstructive pulmonary diseases with acute exacerbation (AE-COPD) were selected as pathologic study object,and 40 healthy volunteers during the same period were selected as the controls.The induced sputum before (Group AE-COPD) and after the treatment (Group S-COPD) were prepared and its Th17 related cytokines level (IL-23,IL-1β,IL-17A and IL-17F) were tested.Its correlation with BODE index and GOLD degree were analyzed. Results The IL-23,IL-1β,IL-17A and IL-17F levels of Group AE-COPD and Group S-COPD were significantly higher than those of the control group (P<0.05),and IL-23,IL-1β,IL-17A and IL-17F levels of Group AE-COPD were significantly higher than those of Group S-COPD (P<0.05).The BODE index and GOLD degree of Group AE-COPD were significantly higher than those of Group S-COPD (P<0.05).Correlation analysis showed that IL-23,IL-1β,IL-17A and IL-17F levels of Group AE-COPD had positive correlation with BODE index and GOLD grade (P<0.05),and the IL-17A and IL-17F levels of Group S-COPD had positive correlation with BODE index and GOLD grade (P<0.05). Conclusion IL-23,IL-1β,IL-17A and IL-17F are all involved in the occurrence and development of COPD,and their acute phase levels are all positively correlated with BODE index and GOLD grade.
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Key words:
- Chronic obstructive pulmonary disease /
- Induced sputum /
- Th17 cell /
- Cytokines
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