Abstract: Objective To investigate clinical characteristics of Kawasaki disease with no responsiveness immunoglobulin therapy therapy,so as to improve its prevention and treatment. Methods We retrospectively reviewed the clinical data of 158 cases of children with Kawasaki disease from February,2013 to February,2015,those who were sensitive to initial treatment were assigned as sensitive group,use for invalid without as Non-sensitive group.Analysis of the two groups of children with clinical manifestation,laboratory examination,cardiovascular complications and prognosis etc,and no response group treatment again. Results After gamma globulin treatment,132 cases (83.54%) for sensitive people,no responders 26 cases (16.46%).Non-sensitive group of laboratory examination of PLT,ESR,ALT and CK-MB group was significantly higher than sensitive group,but Hgb significantly below the sensitive group,the difference was statistically significant (P<0.05).Non-sensitive group of 26 cases underwent additiona ivIg treatment,glucocorticoid treatment,temperature was normal.Follow-up for a year,two groups of children recovered well. Conclusion High incidence of ivIg no reaction type KD,and coronary artery damage occur more often.Lymph node neck tenderness sex (>2 cm in diameter),skin rashes,PLT,ESR and ALT elevations,Hgb reducing,may be a risk factor for ivIg no reaction type KD.