Abstract: Objective To study the value of ultrasound for evaluation of hepatic vein pressure gradient (HVPG) in patients with HBV infection and cirrhosis. Methods HVPG was measured in 96 patients with HBV infection and cirrhosis in our hospital from July,2014 to March,2016.The patients were divided into three groups according to the results of HVPG:high pressure group (16 cases),normal high value group (28 cases) and normal group (52 cases).The portal vein,the right hepatic vein and the splenic vein were examined by ultrasonography,and the ultrasonographic indexes such as diameter,flow rate,blood flow and congestion index were collected.The variance analysis was used to compare the differences among groups;the correlation between HVPG and ultrasound-related indexes was analyzed by Spearman and Logistic regression analysis.The value of ultrasound diagnosis of HVPG in patients with HBV infection and cirrhosis was evaluated. Results The liver function and portal vein diameter,flow velocity,blood flow and congestion index of the three groups were statistically different (P<0.05).Spearman test showed that liver function and portal vein diameter and congestion index were positively correlated with HVPG (r=0.524,P<0.001;r=0.614,P<0.001;r=0.458,P<0.001),flow velocity was negatively correlated with HVPG (r=-0.378,P<0.039).Logistic regression analysis showed that portal vein diameter and congestion index were independent of HVPG (OR=2.397,P=0.020;OR=2.708,P=0.013). Conclusion There is an independent positive correlation between the portal vein diameter and congestion index and the HVPG,which can be used as the basis for clinical diagnosis and treatment.