Abstract: Objective To analyze the risk factors and clinicopathological features of patients with triple-negative breast cancer. Methods Total 180 cases of breast cancer in our hospital between February,2013 and June,2016 were enrolled into this study.The expression of ER,PR and HRE-2 was detected by immunohistochemical method.The 60 patients with triple-negative breast cancer were chosen as observation group,and the other 120 patients with non-triple-negative breast cancer were chosen as control group.The Age,smoking and drinking history,body mass index (BMI),family history,place of residence,educational background,age of menarche,lactation status,use of contraceptive drugs,parity,age at primiparity,abortion history,menopausal time of the two groups were compared.The indexes with significant differences were screened out for multivariate logistic regression analyses.The risk factors and clinicopathological features of patients with triple-negative breast cancer were analyzed. Results Statistically significant differences (P<0.05) were found in age,body mass index (BMI),lactation status,use of contraceptive drugs,parity,and menopausal time between the patients in the two groups,but not in smoking and drinking history,family history,place of residence,educational background,age of menarche,age at primiparity,abortion history (P>0.05).Multivariate logistic regression analyses showed that the ORs of under the age of 60,twice or more than twice of parity,menopausal time were 2.384,1.213 and 3.324,respectively.The corresponding P values were all greater than 0.05,and there was no statistical significance.The ORs of body mass index,lactation status,use of contraceptive drugs were 5.789,5.672 and 8.932,respectively.The corresponding P values were all less than 0.05,and there was statistical significance.BMI ≥ 25 kg/m²,suppression of lactation and the use of contraceptive drugs were risk factors of triple-negative breast cancer.The main pathological type of triple-negative breast cancer was invasive ductal carcinoma,with higher incidence of lymph node metastasis.The tumor staging and grading of triple-negative breast cancer were advanced. Conclusion The malignant degree of triple-negative breast cancer is higher than that of non-triple-negative breast cancer.Obesity,suppression of lactation and the use of contraceptive drugs is risk factors of triple-negative breast cancer.