Abstract: Objective High-grade aneurysmal subarachnoid hemorrhage (aSAH) has high morbidity and mortality,craniotomy and interventional operation is the main treatment,but their effect is still controversial.The aim of this study is to explore the efficacy of interventional embolization,and to provide the basis for clinical treatment in patients with aSAH. Methods A total of 90 patients with high-grade aneurysmal subarachnoid hemorrhage were divided into observation group (49 cases) and control group (41 cases) from June,2011 to May,2016.The patients of the observation group received interventional embolization,while the control group received surgical clipping of a cerebral aneurysm.The levels of IgA,IgG and IgM,hospitalization time,complications and short-term efficacy were compared between 2 groups. Results The levels of IgA,IgG and IgM had no significant difference between the two groups before the operation (P>0.05);as compared with the levels before operation,the levels of IgA,IgG and IgM decreased significantly at 24 h after the operation in both groups (P<0.05),and the control group decreased more significantly than those of the observation group (P<0.05).The hospitalization time and cerebral vasospasm incidence in the observation group was significantly lower than that in the control group (P<0.05),but the incidence of rehemorrhage,hydrocephalus and intracranial infection had no significant difference between the two groups before the operation (P>0.05);The short-term better prognosis rate of the observation group was 71.43%,which was significantly higher than that of the control group (48.78%),P<0.05. Conclusion Interventional embolization has better short-term efficacy on high grade aneurysmal subarachnoid hemorrhage with less influence on immunologic function.It can shorten the length of hospital time,reduce the incidence of cerebral vasospasm.