Abstract: Objective Thoracoscopy is widely used in the treatment of lung cancer.There is little research on the efficacy of single-port and three-port methods in the treatment of patients with early non-small cell lung cancer.The clinical efficacies of the two methods are still controversial. Methods We collected 116 cases of early non-small cell lung cancer patients admitted to our hospital from January,2015 to June,2016.According to the treatment methods,they were divided into the single-port and the three-port group.The 52 cases in single-port group was given radical resection of pulmonary carcinoma with single port thoracoscopy,while the 64 patients in the three-port group was treated with radical resection of pulmonary carcinoma with three-port thoracoscopy.Comparative analysis of operation time,intraoperative blood loss,number of lymph node dissection,the total length of the incision,converted to open surgery,postoperative drainage,drainage time,hospitalization time,patient satisfaction score,postoperative pain score of first days,third day postoperative pain score and postoperative complication rate was made between the two groups. Results All patients underwent surgery successfully.Compared with those of the three-port group,the operation time and the amount of bleeding were significantly more,the total length of the incision was shorter,postoperative drainage was less,satisfaction score was higher,postoperative first day and third days pain scores were lower,with statistical significance (P<0.05),while the number of lymph node dissection,the number of cases converted to open surgery,the incidence of thoracic drainage time,hospitalization time and postoperative complications showed no significant difference between the two groups (P>0.05). Conclusion The ideal clinical effect can be achieved with both single-port and three-port thoracoscopic radical resection of pulmonary carcinoma,and the safety of the operation can be guaranteed,with less postoperative pain and better incision appearance,which is worthy of further clinical application.