Abstract: Objective To investigate the efficacy and safety of low-dose misoprostol in the labor induction in patients with severe preeclampsia. Methods A total of 60 severe preeclampsia women with an unfavourable cervices (Bishop Score ≤ 5 scores) were collected for retrospective analysis.They were randomized for labor induction with either low-dose misoprostol (30 cases) or dinoprostone (30 cases).The rate of vaginal delivery and the maternal-neonatal adverse reactions between the two groups were compared. Results The vaginal delivery rate in low-dose misoprostol group and dinoprostone group were 76.67% and 73.33%,respectively,there was no statistically difference (P>0.05).They were both effective in promoting cervical ripening,the increase in Bishop score was 2.84±0.74 vs.2.68±0.88,P>0.05.The induction-to-labor interval was longer in the misoprostol group[(11.13±2.02) h]than that in the dinoprostone group[(9.43±1.72) h]when the Bishop score<4,P<0.01,and there were no difference between the two groups[(6.67±2.53) h vs.(6.34±2.12) h]when the Bishop score ≥ 4,P>0.05.The difference of total stages of labor were not significant[(6.33±1.04) h vs.(6.20±1.22) h],P>0.05.Compared with the misoprostol group,the blood pressure were higher in the dinoprostone group when being in labor.There was no difference in the rate of asphyxia,postpartum hemorrhage and other adverse reactions between the two groups (P>0.05). Conclusion Low-dose misoprostol is safe and effective in the labor induction in patients with severe preeclampsia.The blood pressure can maintain relatively stable during the induction of labor,and the maternal tolerance is better.It can improve the rate of vaginal delivery,and is worthy of clinical application.