Abstract: Objective To investigate the clinical efficacy of uremic clearance granule combined with losartan in the treatment of hypertension with hyperuricemia. Methods Total 168 cases of hyperuricemia with hyperuricemia in our hospital between January, 2015 and March, 2016 were selected and divided into observation group and control group (n=84) by random number method.The patients in the control group were given losartan, while the patients in the observation group were added uremic clearance granule based on losartan.Before and after the treatment, blood and uric acid indicators[systolic blood pressure (SBP), diastolic blood pressure (DBP), and uric acid (UA)], endothelial cell function[nitric oxide (NO), Von Willebrand factor (vWF)], RAS activity indicators[plasma supine renin, Angiotensin Ⅱ (Ang Ⅱ)], blood lipids indicators[triglycerides (TG), cholesterol (TCG) and high density lipoprotein (HDL-1)]of two groups were tested, and the adverse reactions and clinical efficacy of the two groups were accounted. Results After the treatment, the levels of SBP, DBP, uric acid, vWF, adrenaline, Ang Ⅱ, TG and TCG HDL-C in both groups were significantly reduced (P <0.05), and each indexes of the observation group were significantly lower than those of the control group (P < 0.05).The NO levels of the two groups were significantly increased (P < 0.05), NO level of the observation group was significantly higher than that of control group (P < 0.05).The total effective rate of the observation group was 91.7%, which was significantly higher than that of control group (79.8%), P < 0.05. Conclusion Uremic clearance granule combined losartan could inhibit the over-activation of RAS system, improve the function of endothelial cells, effectively reduce the blood pressure and blood uric acid content, with satisfactory treatment.