Abstract: Objective To investigate the risk factors of intrahepatic cholestasis of pregnancy (ICP) and its influence on pregnancy outcome. Methods The clinical data of 40 patients with ICP in the second affiliated hospital of Zhengzhou university from September, 2013 to September, 2016 were analyzed, and 70 healthy pregnant women in the same hospital were selected as the control group, then the risk factors of ICP were analyzed.In addition, the perinatal gestational age and birth weight of both groups were recorded, and perinatal distress, amniotic fluid meconium contamination, premature delivery, aspiration pneumonia, asphyxia, pregnancy adverse events and perinatal complications of both groups were recorded and compared. Results The ratio of combined with hepatitis B or other hepatobiliary disease, ICP history, concomitant twins, and pregnancy complication of the ICP group were significantly higher than those of the control group, the differences were statistically significant (P < 0.05).The incidence rate of perinatal distress, amniotic fluid pollution, asphyxia, premature delivery and low birth weight infants of the ICP group were significantly higher than those of the control group, the differences were statistically significant (P < 0.05).The ratio of hypertensive disease of pregnancy, premature rupture of membranes, postpartum hemorrhage of ICP group were significantly higher than those of control group, the differences were statistically significant (P < 0.05). Conclusion Hepatitis B or other hepatobiliary diseases, ICP history, twins, pregnancy complications were the risk factors of cholestasis syndrome during pregnancy.ICP could increase perinatal distress, amniotic fluid meconium contamination, premature delivery, inhalation pneumonia, asphyxia and perinatal complications, effect the perinatal growth, and result in a poor outcome.