Abstract: Objective To investigate the possible mechanism and risk factors of early cardiovascular disease in obese children. Methods From June, 2016 to December, 2016, a total of 100 obese children in our hospital were selected as the research object, and they were divided into mild group and moderate and severe obesity group according to BMI (body mass index).Sixty healthy children in our hospital during the same period were selected as control group.To study the human morphology parameters indexes including blood pressure, height, BMI, waist circumference, lipid metabolism index (blood glucose, blood lipid), vascular endothelial growth factor (VEGF), platelet derived growth factor (PDGF-BB) and its receptor (PDGFR-2) expression levels, arterial intima-media thickness (IMT).Logistic regression was used to analyze the risk factors of cardiovascular disease in obese children. Results The age and IMT value in children with moderate and severe obesity group was higher than that of mild obesity group (P < 0.05).The F variance analysis showed that the observation group and control group in blood pressure, waist circumference, BMI, FPG, TC, TG, VEGF, PDGF-BB, PDGFR-2 expression level were statistically significant differences (P < 0.05).Logistic regression analysis showed that blood pressure, BMI, waist circumference, FPG, TG, VEGF, PDGF-BB and PDGFR-2 were correlated with the IMT of obese children (P < 0.05), which were the risk factors of early vascular disease. Conclusion Obese children are more prone to hypertension, abnormal expression of lipid metabolism and glucose, VEGF, and PDGF-BB and PDGFR-2 abnormal expression.All the above indexes was correlation with IMT in obese children, it is the risk factors for the occurrence of early vascular disease.