Abstract: The infection of the central nervous systems (CSF) is a kind of disease of nervous systems, the diagnose of which is mainly confirmed by cerebrospinal fluid's culture through lumbar puncture.Because of different pathogens, the pathogenesis, pathophysiology, severity of acute phase and prognosis are different, but each can lead to many complications, such as visual impairment, hearing impairment, secondary epilepsy, brain abscess and so on.Because early symptoms are not typical, the diagnosis is not timely, resulting in delaying treatment, so morbidity and mortality of central nervous's infection are high.Early assessment of prognosis is helpful to improving the life quality of patients, reducing the burden of the family.The current assessments of CNS infection mainly depends on health care including the development of intelligence and movement, or relies on imaging, such as magnetic resonance and CT, or the application of electrophysiological methods.Visual impairment is a kind of complications after central nervous infection.Because the incidence of visual impairment is not easy to find, it is too late to find until blindness.Visual evoked potential (visual evoked potential, VEP) is a kind of method extracting from electroencephalogram (EEG), which is easier to learn and to analyze than EEG.It is different from MRI or CT, which is dominant to find the lesion of the nervous system.The visual evoked potential is gradually applied to the infection of central nervous system, and to infer the development and integrity of nervous system.This paper mainly relies on reading literature and sums up the application in nervous system infection, and explores the value of its prognosis.