Effects of moxibustion at Guanyuan and Qihai points on quality of life in patients with advanced liver cancer
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摘要: 目的 探讨艾灸关元、气海穴对晚期肝癌患者生存质量的影响的临床观察。 方法 将台州市第一人民医院2013年9月—2015年8月确诊的60例晚期肝癌患者分为2组。对照组采用对症治疗。治疗组在对照组基础上,采用艾灸关元、气海穴。对比2组临床症状改善情况。于治疗前后,对比2组治疗前后CD3+、CD4+、CD4+/CD8+、NK细胞的变化。采用生命质量测定量表(QOL-LC)评估患者治疗前后生存质量的变化情况,包括躯体功能、心理功能、症状及副作用、社会功能及总体健康评分。 结果 治疗后,2组的中医症状评分显著降低(P<0.05);治疗组治疗后中医症状评分显著低于对照组,差异有统计学意义(P<0.05);治疗组治疗后CD3+、CD4+、CD4+/CD8+、NK细胞均显著升高(P<0.05);治疗后,治疗组CD3+、CD4+、CD4+/CD8+、NK细胞的水平显著高于对照组,差异有统计学意义(P<0.05);对照组治疗前后CD3+、CD4+、CD4+/CD8+、NK细胞无显著性改变(P>0.05);治疗组治疗后躯体功能、心理功能、社会功能、总体健康评分均显著升高(P<0.05);治疗后,治疗组躯体功能、心理功能、社会功能、总体健康评分的水平显著高于对照组,差异有统计学意义(P<0.05);对照组治疗后心理功能、总体健康评分显著升高(P<0.05)。 结论 艾灸关元、气海穴改善晚期肝癌患者免疫功能,提高生存质量。Abstract: Objective To investigate the effect of moxibustion at on Guanyuan and Qihai points on quality of life of patients with advanced liver cancer. Methods Total 60 patients with advanced liver cancer in our hospital between September 2013 and August 2015 were enrolled and divided into two groups.The control group received the symptomatic treatment, while the treatment group received additional moxibustion at Guanyuan and Qihai based on the therapy in the control group.The improvement of clinical symptoms in the two groups was compared.Before and after the treatment, the changes of T lymphocyte subsets (CD3+, CD4+, CD4+/CD8+) and NK cells in the two groups were compared.Quality of life (QOL-LC) was used to assess the quality of life of patients before and after the treatment, including physical function, psychological function, symptoms and side effects, social function and overall health score. Results The scores of TCM symptoms of the two groups were significantly decreased after the treatment (P < 0.05), TCM symptom scores of the treatment group were significantly lower than those of the control group, the difference was statistically significant (P < 0.05).CD3+, CD4+, CD4+/CD8+ and NK cells in the treatment group were significantly increased (P < 0.05), and were significantly higher than those in the control group, the difference was statistically significant (P < 0.05).In the control group, there were no significant difference in CD3+, CD4+, CD4+/CD8+ and NK cells before and after the treatment (P >0.05);After the treatment, the physical function, psychological function, social function and overall health score of the treatment group were significantly increased (P < 0.05), and were significantly higher than those of the control group, the difference was statistically significant (P < 0.05).The psychological function and overall health score of the control group were significantly increased (P < 0.05). Conclusion Moxibustion at Guanyuan and Qihai point can improve immune function and QOL of patients with advanced hepatocellular carcinomato.
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Key words:
- Moxibustion /
- Guanyuan point /
- Qihai point /
- Advanced liver cancer /
- Quality of life /
- Immune function
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