Abstract: Objective To evaluate the effects of preoperative prophylaxis nutrition support on the recover index in patients with colorectal cancer. Methods Sixty cases of colorectal cancer (NRS-2002 ≥ 3) in our department from April to September in 2016 were randomly assigned into control group (n=30) and experiment group (n=30).All the patients in both groups took the routine diet, while the patients in the experiment group consumed 1 500 ml of protein-type enteral nutrition Risai produced by Huarui Pharmaceutical Co Ltd at 3 days before the operation.PA, ALB and HB before the operation and 3 days after the operation, body weight on the third day after operation, tiem for first flatus passing, self-care ability 3 days after operation (Barthel, HBB), and postoperative complications (pulmonary infection, incision healing, anastomotic fistula) were compared between the two groups. Results The level of PA[(175.02 ±6.39) mg/L], ALB[(34.73 ±3.53) g/L]and HE[(108.45 ±9.45) g/L]3 days after the operation in the experimental group were significantly higher than those of the control group (P < 0.05).The first flatus passing[(56.84 ±12.35) h] and first oral feeding[(66.77 ±13.59) h] in the experimental were significantly earlier than those in the control group (P < 0.05).The Barthel score at 3 days after the operation in the experimental group (62.80 ±4.88) was significantly higher than that (52.16 ±9.62) in the control group (P < 0.01).There was not obvious difference in body weight at 3 days after the operation and postoperative complications between the two groups. Conclusion For the colorectal cancer patients with risks of low nutrition, the preoperative nutritional support can effectively improve the postoperative nutritional status, minimize the surgical stress response and improve the patient's physical and mental health in order to promote the rehabilitation of patients.