Abstract: Objective To explore the effect of collaborative nursing model on radial artery occlusion after trans-radial percutaneous coronary intervention and patient and their family satisfaction. Methods The clinical data of 84 consecutive patients undergoing trans-radial percutaneous coronary intervention in our hospital between September, 2015 and December, 2016 were retrospectively analyzed.Forty-two cases in the observation group received the cooperative nursing model, while 42 cases in the control group received the routine nursing model.The incidence of radial artery occlusion after surgery was recorded.The patient and their family satisfaction questionnaire surveys were carried out.The occurrence of radial artery occlusion and nursing satisfaction were compared between the two groups by χ²test. Results The incidence of radial artery occlusion after trans-radial coronary intervention in the observation group was 2.4% (1 case) and the nursing satisfaction was 100% (42 cases);while those in the control group was 19.1% (8 cases) and 85.7% (36 cases).There was significant difference in the incidence of radial artery occlusion and nursing satisfaction between the two groups (P <0.05). Conclusion Collaborative nursing model can significantly reduce the incidence of radial artery occlusion after trans-radial coronary intervention, and effectively increased patient compliance with treatment and care satisfaction, significantly improve the ability of communication between doctors and patients.