Abstract: Objective To reveal and analyze the current situation of comprehensive management among 45 to 59 years diabetes mellitus in Hudong community. Methods From October, 2013 to May, 2014, we selected permanent residents aged 45 to 59 as subjects from Shanghai Hudong community service center. According to the principle of cluster sampling, the survey was conducted 8 from 33 neighborhood committees, thus it enrolled altogether 1 104 subjects. The study included questionnaire survey (gender, age etc), physical examination (body mass index, blood pressure) and laboratory exanimation (blood glucose, blood lipid etc). We judged the subjects by comprehensive control target based on the "Chinese type 2 diabetes prevention guides (2013 Edition) ". Results The study finally enrolled 1 018 subjects. The prevalence of diabetes was 12. 38% and the awareness rate was 73. 81%. The compliance rate of Fasting blood glucose and glycosylated hemoglobin in female were both lower than those in male, and the differences were statistically significant (P < 0. 05). The compliance rate of combined hypertension, blood lipid and body mass index had no difference in different genders. With the increasing of BMI, the prevalence of diabetes mellitus also increased, with statistical significance (P < 0. 01). The smoking rate was higher in male than that in female among pre-diabetic group, and the difference was statistically significant. We divided the subjects as non diabetic group, pre-diabetic group and diabetic group, and analyzed by Cochran-Armitage trend test, then found that the smoking rate gradually increased, while the compliance rate of BMI gradually decreased, and the difference was statistically significant (P < 0. 01). Conclusion We need to improve the management rate of fasting blood glucose in middle aged female diabetic patients in our community. The Prevalence of pre-diabetic was 13. 06%, and we need to strengthen the intervention of unhealthy lifestyle such as smoking and overweight among them.Our investigation indicated that the primary prevention of diabetes mellitus should be stricter. In order to promote effective community management based on the guideline both domestic and abroad, general practitioners should pay more attention to pre-diabetics, and intervention of related risk factors.