Abstract: Objective To discuss the application effect of "problem-based learning (PBL) "teaching model combined with "case-based learning (CBL) "teaching model in gastrointestinal surgery interns teaching activities. Methods A total of 96 class 2012 undergraduate clinical interns of Wannan Medical College in Yi Jishan Hospital were randomly divided into research group and control group, each group containing 48 cases. PBL combined with CBL teaching model were given in research group while LBL teaching model was conducted in control group to compare the differences of application effect. Questionnaire survey and theory test were carried out to evaluate the teaching effect. With SPSS 15. 0 statistical analysis package and mean ±standard deviation representing measurement data, we compared by one-way analysis variance between groups and by chi-square test for enumeration data. Results The theory test score, comprehensive ability score and total score in research group were all higher than those in control group, and the differences between two groups were statistically significant (all P < 0. 05). The self-study ability, clinical thinking ability, problem analysis and solving skills, communication skills, teamwork ability and data query efficiency of the interns in research group were better than those in control group, and the differences between two groups were statistically significant (all P < 0. 05). Conclusion PBL combined with CBL teaching model has obvious advantages in gastrointestinal surgery clinical intern teaching, which can arouse studying initiative, develop ability to analyze and solve problems and improve the comprehensive quality of interns.So PBL combined with CBL teaching model is worth taking in clinical teaching.