Abstract: Objective To evaluate the application of swallowing assessment based on the theory of DMAIC. Methods From March, 2015 to September, there were 161 medical nurses as the research object, based on the definition, measurement, analysis, improvement and control of the five steps, to establish the key factors to improve the nurses' bedside swallowing assessment, strengthen training and develop process guidelines, thus promoting the compliance of the nurses as well as sustaining quality control. he degree of grasping the swallowing assessment along with the ability of clinical nursing was compared before and after the application of DMAIC, which serves to analyze the efficacy of DMAIC-based swallowing assessment. Results The bedside swallowing assessment score before intervention was (1. 95 ±1. 12), after was (2. 59 ±1. 00), and the difference was statistically significant (t=-5. 339, P < 0. 001). The clinical nursing skill was increased in which the nurses pay close attention to the patient before feeding, the level of consciousness and the higher brain functions (t=-3. 834, P < 0. 001); focus on eating posture, way, content, time, food intake (t=2. 313, P=0. 021); observed after eating whether there were choking, cough, throat clearing situation (t=4. 884, P < 0. 001); to observe the oral food residues, chest food blockage (t=2. 588, P=0. 010); attention to the strange sensation of the throat, saliva secretion (t=-2. 839, P=0. 005); pay attention to reflux (t=4. 671, P < 0. 001). Conclusion The application of DMAIC can promote the improvement of clinical swallowing assessment technology, and has achieved good results, which is worthy of popularizing and applying.