Abstract: Objective To study the effect of deep sedation on severe craniocerebral injury patients after operation. Methods Thirty-seven patients with severe traumatic brain injury from June, 2013 to June, 2016 were treated with routine treatment and deep sedation (BIS:20-40). At the same time 41 patients with severe traumatic brain injury who were not treated by deep sedation (BIS:40-60) were the control group. Two groups of patients had sedative and analgesia treatment, capacity management, mechanical ventilation, nutritional support and other treatment measures. Blood samples were taken to observe the Sj O₂, AVDO₂ and CEO₂indexes of the two groups. The ONSD values of the two groups were measured by bedside color high frequency linear array probe. The diastolic Vd and PI of the middle cerebral artery of the two groups were measured by low frequency micro-convex array probe. We compared the two groups of treatment. Results The mean ONSD (4. 98 ±0. 09) was significantly lower in the experimental group than that in the control group (5. 95 ±0. 05) at the7 th day. The difference was statistically significant (P < 0. 01). In the experimental group, Vd increased and PI decreased at the 7th day. Compared with the control group, the difference was statistically significant (P < 0. 01). In the experimental group, Sjv O₂ increased, but AVDO₂ and CEO₂decreased at the 7th day. Compared with the control group, the difference was statistically significant (P < 0. 01). Conclusion Deep sedation in severe traumatic brain injury can decrease intracranial pressure and improve cerebral oxygen metabolism, which is worth popularizing in clinic.