Abstract: Objective To assess the indications, clinical application value and advantages of Dynesys non-fusion pedicle screw-based stabilization system in the treatment of lumbar degenerative disc disease. Methods Total 40 cases of lumbar degenerative disc disease (male 28, female 22, with an average age of 41) in our hospital between 2008 and 2015 were reviewed retrospectively. The preoperative imaging examinations included lateral and dynamic X-rays of the lumbar spine, plain scanning and 3D reconstruction for vertebrae and disc space, MRI functional score for lumbar vertebra. Posterolateral approach Dynesys non-fusion pedicle screw-based stabilization system was performed in all cases. The Japanese Orthopaedic Association (JOA) and Oswestry Disability Index (ODI) score were employed to assess the clinical efficacy and improvement rate before and after the operation. The results were put into statistical analysis. Results Fourty patients were followed up for 12 to 90 months with an average of 52. At the final follow-up, the excellent and good rate by JOA score was 80. 0%, and ODI decreased from 42. 864 ±5. 528 to 9. 438 ±2. 649, VAS for pain also decreased obviously, the difference was statistically significant (P < 0. 05). There was no intervertebral space infection, lumbar intervertebral instability and failure in internal fixation during the follow up. Conclusion Dynesys system is an effective method for lumbar spine degeneration in preventing adjacent disc degeneration, reserving lumbar physiological movement and improving lumbar instability, shows similar effect in improving the symptoms of low back pain with conventional posterior lumbar fusion surgery.