Abstract: Objective To investigate the effects of interbody fusion combined fusion fixation pedicle screw in the treatment of spinal stenosis. Methods A prospective study was carried out among 130 spinal stenosis patients in our hospital from August, 2011 to February, 2015. The patients were randomly divided into the treatment group and the control group with 65 cases in each group. The control group received conventional treatment of spinal arthroplasty, while the treatment group received lumbar interbody fusion combined pedicle screw fixation. Results All patients were successfully operated. The operative time, blood loss and postoperative hospital stay in the treatment group were significantly less than those in the control group (P < 0. 05). The postoperative three months of pulmonary infection, incision infection, intervertebral instability and vascular injury in the treatment group were 1 case, 0 case, 1 case, 1 case, so that were 4 cases, 5 cases, 6 cases, 7 cases in the control group, the treatment was significantly less than the control group (P < 0. 05). The postoperative (three months after operation) excellent rates in the treatment group were 93. 8%, and in the control group was 84. 6%, the excellent rate of the treatment group was significantly higher (P < 0. 05). Conclusion The lumbar interbody fusion combined pedicle screw fixation in the treatment of lumber spinal stenosis can provide strong fixation, with better efficacy and safety, thus contributes to the function of the lumbar spine recovery.