Abstract: Objective To observe attention network system and therapy effect of acupuncture therapy of Tong Du Tiao Shen for regulating mentality in post stroke aphasia patients. Methods Twenty cases of post stroke aphasia patients from June, 2014 to December, 2015 were randomly divided into treatment group (10 cases) and control group (10 cases). The treatment group accepted acupuncture therapy of Tong Du Tiao Shen for regulating mentality, and the control group accepted routine acupuncture therapy. hey were assessed with attention network test (ANT) and Western aphasia battery (WAB) before and 4 weeks after intervention. Results After 4 weeks, the alerting network efficiency and accuracy of ANT increased and the executive network efficiency and total reaction time of ANT decreased significantly in treatment group (P < 0. 05), and the score of aphasia quotient (AQ) increased significantly in both treatment group and control group (P < 0. 05). The alerting network efficiency, executive network efficiency, total reaction time and accuracy of ANT (P <0. 01) and the score of AQ (P < 0. 05) improved more in the treatment group than in the control group. Conclusion Acupuncture therapy of Tong Du Tiao Shen for regulating mentality is more effective on alerting network and executive network of attention network system than routine acupuncture therapy, which could promote the recovery of language function in post stroke aphasia patients.