Abstract: Objective To observe cerebral protection effect of parecoxib sodium in elderly patients with colon and rectum carcinoma operation. Methods Seventy-two cases of elderly patients with colorectal cancer surgery included in the study were randomly divided into 2 groups, 36 cases in each group. The observation group and control group were respectively accepted intravenous injection of parecoxib sodium of 0. 6 mg/kg before induction, normal saline after intravenous injection of 0. 3 mg Thorning, 0. 05 mg/kg midazolam, fentanyl 3 g/kg, 1-1. 5 mg/kg 0. 15 mg/kg propofol, CIS atracurium besylate for induction of anesthesia, intraoperative infusion 4-8 mg/(kg·h) propofol and intermittent intravenous fentanyl 0. 05 mg, 5 mg cis-atracurium to maintain BIS in 40-60. Two groups were recorded after the burglary, after induction of surgical 1 h after tracheal intubation, the end of surgery, hemodynamic indexes; and after the burglary, the end of surgery, postoperative 12 h, postoperative 24 h, postoperative 48 h venous blood serum S100 protein, neuron specific enolase (NSE) levels were statistically analyzed; the incidence of adverse reactions were compared between the two groups. Results The T₂, T₃ time MAP and HR level in the observation group were lower than the control group (P < 0. 05), T₂, T₃ time MAP and HR were lower than those of T₀ (P < 0. 05), the observation group was more stable hemodynamics; the observation group was given parecoxib sodium, T₁, T₂, T₃, T₄, serum S100 beta protein level of NSE were lower than the control group (P < 0. 05); and the 2 groups of T₁, T₂, T₃, T₄, serum S100 protein, NSE levels were higher than the level of T₀ (P < 0. 05). Two groups of patients with adverse reaction rate difference was significant (P > 0. 05). Conclusion For elderly colorectal cancer root treatment of patients, Pparecoxib sodium can stable blood flow dynamics, and the brain protection effect is good, safe in clinical application.