Abstract: Objective To investigate the effect of tripterygium wilfordii polyglycosides combined telmisartan on renal function and hemorheology in patients with diabetic nephropathy. Methods Two hundred and sixteen cases of diabetic nephropathy were randomly divided into two groups, with 108 cases in each group. The patients in the control group received telmisartan, while the patients in the observation group received additional tripterygium wilfordii polyglycosides. Before and after the treatment, the renal function indicators (Urine β2-MG, UAER, UP and GFR), blood biochemical indicators (WBC, Scr, Bun, Hb A1c), hemorheology (PV, PF, HBV, LBV) of both groups were detected. And the total effective rate of two groups were accounted. Results After the treatment, β2-MG, UAER, UP and GFR levels of both groups were significantly improved (P < 0. 05), and the β2-MG, UAER, UP and GFR improvements of the observation group were significantly better than those of the control group (P < 0. 05). After the treatment, WBC, Scr, Bun and Hb A1 c levels of both groups were significantly improved (P < 0. 05), and the WBC, Scr, Bun and Hb A1 c improvements of the observation group were significantly better than those of the control group (P < 0. 05). After the treatment, PV, PF, HBV and LBV levels of both groups were significantly improved (P < 0. 05), and the PV, PF, HBV and LBV improvements of the observation group were significantly better than those of the control group (P < 0. 05). The total effective rate of the observation group was 90. 7%, which was significantly higher than that of control group (79. 6%, P < 0. 05). Conclusion Tripterygium wilfordii polyglycoside combined with telmisartan could effectively improve the renal function and hemorheology of patients with diabetic nephropathy, with satisfactory effect.