Abstract: Objective To observe the effect of Huoxue Huazhuo capsule on C-reactive protein (CRP), platelet aggregation rate and symptom scores in patients with unstable angina (UA). Methods Total 60 patients meeting the inclusion criteria of unstable angina were assigned by the random number table into treatment group and control group with 30 cases in each group. All the patients received the basic treatment and intravenous drip 40 mg isosorbide mononitrate once a day, and the treatment group received additional Huoxue Huazhuo capsule 3 pills and 3times once a day. The efficacy indicators were observed after the treatment. Student t-test and Ridit analysis were used to statistical analysis of the data. Results The total effective rate of the treatment group was better than the control group (P < 0. 05), which had statistical significance.ECG:there was no significant difference between the treatment group and the control group (P > 0. 05). There were significant differences between the TCM syndrome scores before and after the treatment (all P < 0. 05). There was a significant difference in CRP between the two groups before and after the treatment (P < 0. 05):the treatment group was superior to the control group (P < 0. 05). There was significant difference in platelet aggregation rate between the two groups before and after the treatment (P < 0. 01):the treatment group was better than the control group (P < 0. 01). Conclusion Huoxue Huazhuo capsule can reduce C-reactive protein, stabilize plaque, improve platelet aggregation rate, prevent thrombosis, strengthen the role of anti-atherosclerosis, prevent from angina pectoris.