Abstract: Objective To investigate the effect of Yiqi Jianpi method combined with probiotics on serum inflammatory factors in patients with inflammatory bowel disease. Methods A total of 114 cases of inflammatory bowel disease were selected from April, 2015 to September, 2016 in our hospital as the research object. All patients were divided into study group and control group according to the random number table method, with 57 cases in each group. The study group received Yiqi Jianpi method combined with triple viable capsule of bifidobacterium. The control group was treated with triple viable capsule of bifidobacterium. Observe the improvement of clinical symptoms in the two groups, and the TCM symptom score, disease activity (DAI) index, mucosal image score. Before and after treatment, the level of C reactive protein (CRP), tumor necrosis factor A (TNF-α), interleukin 6 (IL-6), interleukin 1 beta (IL-1 beta) were compared between the two groups. Results The efficacy of the study group was significantly better than that of the control group, and the difference was statistically significant (P < 0. 05). After treatment, the TCM symptom score, DAI index, and mucosal image score of the two groups were significantly decreased (P < 0. 05). After treatment, the TCM symptom score, DAI index, mucosal image score in the study group were significantly lower than those in the control group, with statistically significant difference (P < 0. 05). After treatment, CRP, TNF-α, IL-6, IL-1 of the both groups were significantly reduced (P < 0. 05).After treatment, the CRP, TNF-α, IL-6 and IL-1 in the study group were significantly lower than those in the control group and the difference had statistical significance (P < 0. 05). Conclusion Yiqi Jianpi method combined with probiotics can significantly improve the clinical symptoms in patients with inflammatory bowel disease as well as inflammatory reaction.