Abstract: Objective To study the effect of oral cavity irrigation nursing in transfusion room on postoperative recovery of oral and maxillofacial region. Methods From July, 2014 to July, 2016, 136 cases of oral and maxillofacial surgery in our hospital were randomly divided into observation group and control group. The control group received routine oral rinse nursing, the observation group received oral transfusion room nursing. Comfort, oral cleanliness and oral care satisfaction were observed, recorded and compared between the two groups after oral rinse. Results In the observation group, 59 cases were comfortable, 6 cases were general comfortable, 3 cases were uncomfortable, total comfort degree is 95. 59%. In the control group, 21 cases were comfortable, 21 cases were general comfortable, 26 cases were uncomfortable, the total comfortable degree was 61. 76%, there was statistically significant difference (P < 0. 05). Patients in the observation group were 3 cases of oral cleanliness of the patients, accounting for 80. 88% of the control group, oral cleanliness of the patients with a total of 3 cases, accounting for 50%, the difference was statistically significant (P < 0. 05). The observation group of oral rinse very satisfactory in 37 cases, 19 cases were satisfactory, 11 cases were basically satisfied, 1 case was unsatisfied, the total satisfaction rate was 98. 53%, the control group of oral rinse very satisfactory in 13 cases, 14 cases were satisfactory, 10 cases were basically satisfied, not satisfied with 19 cases, 12 cases were unsatisfied, the total satisfaction was 54.41%. There was statistically significant difference (P < 0. 05). Conclusion The effect of infusion irrigation on postoperative recovery of patients with oral and maxillofacial surgery is significant, which can effectively improve the comfort degree of patients and the degree of oral cleanliness, and improve the satisfaction rate of nursing care.