Abstract: Objective To explore the postoperative temperature nursing intervention and its value based on the ulinastatin (UTI) for the congenital heart disease children by the cardiopulmonary bypass. Methods We selected 78 congenital heart disease children admitted to our hospital from August, 2011 to April, 2015 and randomly divided into the observation group and control group, with 38 patients in each group. Both groups were given cardiopulmonary bypass, on the basis of which the observation group was given the UTI infusion of lung preservation solution together with positive nursing intervention. Results The observation group 2 h postoperative body temperature[(37. 46 ±0. 43)℃]and 24 h postoperative body temperature[(38. 28 ±0. 56)℃] were significantly higher than that of the control group[(36. 12 ±0. 48)℃, (36. 78 ±0. 46)℃], P < 0. 05. The ventilation time[(27. 45 ±5. 33) d] and postoperative hospital stay[(23. 45 ±4. 31) d] in the observation group were significantly less than the control group[(41. 98 ±6. 13) d and (27. 93 ±4. 09) d, P < 0. 05]. The postoperative 24 h Sjv O₂ values and serum TNF-α values in the two groups were significantly higher than the preoperative (P < 0. 05), but the postoperative 24 h SjvO₂ values[(72. 48 ±6. 09)%]and serum TNF-α values[(7. 98 ±2. 14) pg/ml] in the observation group were significantly lower than the control group[(84. 20 ±5. 68)%, (8. 89 ±1. 54) pg/ml, P < 0. 05]. Conclusion Postoperative temperature nursing intervention based on the UTI for the congenital heart disease children by the cardiopulmonary bypass can effectively inhibit the release of pro-inflammatory cytokines and reduce brain oxygen metabolism, thus it is beneficial to maintain postoperative temperature and promote the rehabilitation of children.