Abstract: Objective To analyze the effect of optimized nursing process on compliance behavior and prognosis of patients with coronary heart disease. Methods One hundred cases of patients with coronary heart disease admitted in a hospital from May, 2013 to September, 2015 were selected as the research object. With informed consent of patients, the object was randomly divided into control group and study group, 50 cases in each group. The routine nursing care was applied to the control group and optimized nursing process intervention to the study group, to compare two groups of patients' satisfaction to nursing care, compliance behavior and prognosis. Results The difference of nursing satisfaction between the two groups was statistically significant (Z=3. 025, P=0. 002). The comparison of compliance behavior between the two groups, the patients in the study group diet (χ²=5. 263, P=0. 022), exercise (χ²=5. 198, P=0. 023), ban alcohol and tobacco (χ²=5. 741, P=0. 017), take medicine on time (χ²=5. 316, P=0. 021) four aspects was significantly better than the control group, the difference was statistically significant. In terms of prognosis, the number of cardiac death, myocardial infarction, coronary restenosis and stroke in the study group was less than that in the control group. The incidence of cardiovascular events was compared, the study group was significantly better than the control group, the difference was statistically significant (χ²=9. 013, P=0. 003). Conclusion Optimized nursing process can significantly improve the coronary heart disease patients' compliance behavior and prognosis, thus it has important clinical value.