Abstract: Objective To investigate the clinical nursing experience of patients with amputation of toe necrosis after surgery because of acute lower limb ischemia. Methods The nursing data of 18 cases with toe necrosis and amputation as a result of acute arterial ischemia of the lower extremity who were admitted to the First affiliated hospital of Bengbu medical college, department of vascular surgery from January, 2015 to January, 2016, were retrospectively analyzed, including positive psychological counseling, intensive care of the amputation ending, a healthy diet instruction and rehabilitation training. The undesirable wound surface of the first stage was treated via a period of debridement for fresh granulation tissue growth and then underwent vacuum sealing drainage (VSD) for one week. The healing of the amputation ending as well as the patients' recovery was observed. Results There were twelve patients with amputated wounds who were healed in the first stage, five patients who suffered from postoperative fat liquefaction, partly with unhealed incisal margin, after strengthening medicine combined with VSD and sutured in the second stage, three patients suffered from pulmonary infection, four cases patients had heart failure symptoms. After comprehensive treatment and nursing, seventeen cases of patients with amputation wound healed, limb functional exercise is good, pulmonary infection, heart failure symptoms get effective control and postprandial blood glucose levels were below the 9. 0 mmol/L. One case of elderly patient died of heart and lung failure four days after operation. Conclusion The patients with toes amputation surgery because of the acute arterial ischemia of the lower extremity need to cooperate with security, careful nursing and diet health guidance, which is of great significance to promote the rehabilitation, wound healing, reduce complications and improve the quality of life of the patients.