Abstract: Objective To investigate the clinical effect of the different dosage of colchicine on gouty arthritis. Methods Ninety-eight patients admitted to our hospital from March,2015 to June,2016 were randomly divided into group A(n=33),group B(n=33) and control group(n=32).The control group was treated by meloxicam,the group A was treated with a small dose of colchicine based on the control group,and the group B was treated with the conventional dose of colchicine based on the control group.It compared the clinical efficacy,the time of pain relief,the frequency of episodes and recurrence,the level of serum uric acid,erythrocyte sedimentation rate and C reactive protein,and adverse reaction. Results The clinical effective rate was 96.97% in group A,90.91% in group B,which were significantly higher than that of 78.13% in the control group(χ²=10.664,P=0.005).And there was significant difference between the group A and the control group (Z=-3.631,P<0.001).There were statistically significant differences in the time of pain relief,the frequency of episodes and recurrence among three groups(F=9.281,P<0.001;F=4.372,P=0.016;F=6.714,P=0.002).Group A and group B were significantly lower than the control group(P<0.05).After treatment,the level of erythrocyte sedimentation rate and C reactive protein were significantly decreased among three groups (P<0.05),and they were significantly lower in group A and group B than the control group (P<0.05).There was no significant difference in the level of serum uric acid among three groups (P>0.05).The adverse reaction rate of group A was 21.21%,and 12.50% of control group,which were significantly lower than that of 54.55% in the group B(χ²=15.461,P<0.001).And there were significant difference between the group A and B,the group B and the control group (χ²=7.791,P=0.005;χ²=12.827,P<0.001). Conclusion It has a significant clinical efficacy of a small dose of colchicine in the treatment of gouty arthritis.It can effectively shorten the time of pain relief and the frequency of recurrence,reduce the level of erythrocyte sedimentation rate,and high safety,which is worthy of popularization and application.